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In the present study, we attempted to develop a nonspatial delayed match-to-sample task that would aid in assessing the role of the hippocampus in memory. It is difficult to compare directly the results of many past studies of hippocampal function because studies using different species often use very different tasks to assess the same theoretical constructs. Rodent studies typically have used spatial tasks, such as the radial arm maze, with or without delays, whereas primate studies typically have used match-to-sample (MTS) tasks. In the present study, we examined the performance of hippocampal-lesioned rats on nonspatial simultaneous matching-to-sample (SMTS) and delayed matching-to-sample (DMTS) in a cross maze. Postoperatively, the hippocampal-lesioned subjects were unable to reacquire the SMTS task they had learned preoperatively. The results suggest that this approach may provide a useful tool for probing the role of the hippocampus in memory, and that the configurai relationships between stimuli and events or the conditional nature of a learning/memory task may be especially important aspects for determining the impact of hippocampal damage. |
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