Modification of titanium surfaces via surface-initiated atom transfer radical polymerization to graft PEG-RGD polymer brushes to inhibit bacterial adhesion and promote osteoblast cell attachment
| Autor: | Qun Xiao, Yuejiao Gong, Zhi’an Li, Di Liu, Qi Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Materials science Atom-transfer radical-polymerization technology industry and agriculture chemistry.chemical_element 02 engineering and technology Adhesion Polymer 010402 general chemistry 021001 nanoscience & nanotechnology Methacrylate 01 natural sciences 0104 chemical sciences Contact angle chemistry.chemical_compound chemistry Chemical engineering Polymer chemistry Surface modification General Materials Science 0210 nano-technology Ethylene glycol Titanium |
| Zdroj: | Journal of Wuhan University of Technology-Mater. Sci. Ed.. 32:1225-1231 |
| ISSN: | 1993-0437 1000-2413 |
| DOI: | 10.1007/s11595-017-1735-2 |
| Popis: | Implant-related infection is one of the key concerns in clinical medicine, so the modification of titanium to inhibit bacterial adhesion and support osteoblast cell attachment is important. In this article, two strategies were used to examine the above effects. First, modification of titanium via surface-initiated atom transfer radical polymerization (ATRP) was performed. The surface of the titanium was activated initially by a silane coupling agent. Well-defined polymer brushes of poly (ethylene glycol) methacrylate were successfully tethered on the silane-coupled titanium surface to form hydration shell to examine the anti- fouling effect. Second, functionalization of the Ti-PEG surface with RGD was performed to examine the anti-bacterial adhesion and osteoblast cell attachment ability. The chemical composition of modified titanium surfaces was characterized by X-ray photoelectron spectroscopy (XPS). Changes in surface hydrophilicity and hydrophobicity were characterized by static water contact angle measurements. Results indicated that PEG-RGD brushes were successfully tethered on the titanium surface. And anti-bacterial adhesion ability and osteoblast cell attachment ability were confirmed by fluorescence microscopy and scanning electron microscopy. Results indicated that PEG can inhibit both bacterial adhesion and osteoblast cell attachment, while PEG-RGD brushes can not only inhibit bacterial adhesion but also promote osteoblast cell attachment. |
| Databáze: | OpenAIRE |
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