| Popis: |
Rosacea is a chronic inflammatory skin disorder, which seems to have a neurovascular component. Flushing in rosacea has been reported to be associated with a neuropathic burning or stinging pain, and the release of a number of neuropeptides. Associated neuropeptides include vasoactive intestinal peptide, and pituitary adenylate cyclase activating peptide, which both promote neurogenic inflammation and have been related to neurological disorders, namely, migraine. An association between rosacea and several neurological conditions has been suggested, including Alzheimer’s disease, glioma, migraine, and Parkinson’s disease. This chapter critically discusses the presence of neurological comorbidities in rosacea, including possible pathophysiological mechanisms. |
