Mechanisms of action of nonpeptide hormones on resveratrol-induced antiproliferation of cancer cells

Autor:	André Wendindondé Nana, Hung Yun Lin, Guei-Yun Cheng, Hsuan-Yu Lai, Ya-Jung Shih, I-Jen Chiang, Meng-Ti Hsieh, Yu-Chen S.H. Yang, Heng-Yuan Tang, Kuan Wang, Shin-Ying Lin, Yu-Tang Chin
Rok vydání:	2017
Předmět:	0301 basic medicine Cell growth General Neuroscience Integrin food and beverages Biology Resveratrol Pharmacology General Biochemistry Genetics and Molecular Biology Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine History and Philosophy of Science chemistry Hormone receptor 030220 oncology & carcinogenesis Cancer cell biology.protein Signal transduction Receptor Hormone
Zdroj:	Annals of the New York Academy of Sciences. 1403:92-100
ISSN:	0077-8923
DOI:	10.1111/nyas.13423
Popis:	Nonpeptide hormones, such as thyroid hormone, dihydrotestosterone, and estrogen, have been shown to stimulate cancer proliferation via different mechanisms. Aside from their cytosolic or membrane-bound receptors, there are receptors on integrin αv β3 for nonpeptide hormones. Interaction between hormones and integrin αv β3 can induce signal transduction and eventually stimulate cancer cell proliferation. Resveratrol induces inducible COX-2-dependent antiproliferation via integrin αv β3 . Resveratrol and hormone-induced signals are both transduced by activated extracellular-regulated kinases 1 and 2 (ERK1/2); however, hormones promote cell proliferation, while resveratrol induces antiproliferation in cancer cells. Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes. Subsequently, hormones impair resveratrol-induced COX-2-/p53-dependent gene expression. The inhibitory effects of hormones on resveratrol action can be blocked by different antagonists of specific nonpeptide hormone receptors but not integrin αv β3 blockers. Results suggest that nonpeptide hormones inhibit resveratrol-induced antiproliferation in cancer cells downstream of the interaction between ligand and receptor and ERK1/2 activation to interfere with nuclear COX-2 accumulation. Thus, the surface receptor sites for resveratrol and nonpeptide hormones are distinct and can induce discrete ERK1/2-dependent downstream antiproliferation biological activities. It also indicates the complex pathways by which antiproliferation is induced by resveratrol in various physiological hormonal environments. .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::671f9e576d35afe1f7f477f78ff6863e https://doi.org/10.1111/nyas.13423 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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