Chemical imaging of the reconstruction of new bone and trace elements inside bioactive glass scaffoldsin vivo: a multimodal and quantitative micro-ion beam analysis

Autor: Nada Naaman, J.-M. Sautier, Jonathan Lao, Edouard Jallot, J. Nohra, J. Lacroix
Rok vydání: 2014
Předmět:
Zdroj: Surface and Interface Analysis. 46:702-706
ISSN: 0142-2421
DOI: 10.1002/sia.5375
Popis: An original multimodal analysis is proposed for follow-up of bone regeneration inside a SiO2–CaO bioactive glass scaffold in vivo. Classic histological studies are conducted in connection with SEM with backscattered electron imaging and micro-particle induced X-ray emission ion beam analysis, allowing fine morphological characterization and highly sensitive microanalysis of the scaffold/bone interface. The highly bioactive scaffold is entirely changed into bone mineral after 6 weeks of implantation in sheep mandible; thanks to our proposed methodology, it is possible to highlight subtle differences in mineralization and to distinguish between the mineralized scaffold, the newly formed bone and native bone from the trace metal nutrients content. Copyright © 2014 John Wiley & Sons, Ltd.
Databáze: OpenAIRE