Association of plasma proteins with rate of cognitive decline and dementia: 20-year follow-up of the Whitehall II and ARIC cohort studies
| Autor: | Stephen A. Williams, Mika Kivimäki, Henrik Zetterberg, Eric J. Brunner, Ruth C. Lovering, Kalle Saksela, Joni V Lindbohm, Archana Singh-Manoux, Jane E. Ferrie, Gill Livingston, Keenan A. Walker, Pyry N Sipilä, Nina Mars, Aroon D. Hingorani, Rebecca F. Gottesman |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Amyloid business.industry Disease medicine.disease Blood proteins 3. Good health Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders Cohort medicine Dementia Cognitive decline business 030217 neurology & neurosurgery 030304 developmental biology Cohort study |
| Popis: | The role of circulating proteins in Alzheimer’s disease and related dementias is unknown. Using a follow-up of two decades, 4953 plasma proteins, and discovery (Whitehall II) and replication cohort (ARIC), we examined plasma proteins associated with cognitive decline rate and dementia. After replication and adjustment for known dementia risk factors, fifteen proteins were associated with cognitive decline rate and dementia. None of these were amyloid, tau, or neurofilament-related proteins. Currently approved medications can target five of the proteins. The results support systemic pathogenesis of dementias, may aid in early diagnosis, and suggest potential targets for drug development. |
| Databáze: | OpenAIRE |
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