Vitamin B12 Blood Level is Correlated with Drug-Induced Extrapyramidal Symptoms in Schizophrenic Patients
| Autor: | Amelia-Mihaela Dobrescu, Emilia Burada, Otilia Constantina Rogoveanu, Veronica Sfredel, Ileana Marinescu, Tudor Adrian Bălşeanu, Florin Burada, Cito Taisescu |
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| Rok vydání: | 2019 |
| Předmět: |
Blood level
Drug Process equipment Materials Science (miscellaneous) Process Chemistry and Technology media_common.quotation_subject General Engineering General Chemistry General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Extrapyramidal symptoms Materials Chemistry medicine Vitamin B12 General Pharmacology Toxicology and Pharmaceutics medicine.symptom media_common |
| Zdroj: | Revista de Chimie. 70:630-632 |
| ISSN: | 2668-8212 0034-7752 |
| DOI: | 10.37358/rc.19.2.6972 |
| Popis: | The extrapyramidal symptoms (EPS) are commonly associated with antipsychotic treatment of schizophrenic patients. Accumulated evidence has shown that pathways of homocysteine and folate metabolism are linked to neurodegeneration and schizophrenia. The purpose of our study was to evaluate the homocysteine, vitamin B12 and folate serum levels in relation to drug-induced EPS in schizophrenic patients. The blood levels of homocysteine, vitamin B12 and folic acid were measured by chemiluminescent and electrochemoluminescence immunoassay methods in 34 patients diagnosed with schizophrenia (19 patients with severe EPS and 15 controls without EPS), recruited from Clinical Hospital of Neuropsychiatry Craiova, Romania. A significant association has been observed between EPS and vitamin B12 levels, the patients with severe EPS showed a reduced vitamin B12 levels (p=0.02). No correlation was observed between severe EPS and homocysteine or folate levels (p=0.2, respectively p=0.37). Our study suggests that deficiency of vitamin B12 blood levels is correlated with severe EPS in schizophrenic patients. Further studies included more patients and functional experiments are required to clarify the role of these biomarkers in relation with antipsychotic-induced EPS in schizophrenia. |
| Databáze: | OpenAIRE |
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