Evolution of the patient characteristics of candidates for radical prostatectomy and the results obtained with the technique

Autor: I. Arribas-Gómez, M. Sánchez-Chapado, C. Sánchez-Rodríguez, A. Sanchís-Bonet
Rok vydání: 2015
Předmět:
Zdroj: Actas Urológicas Españolas (English Edition). 39:78-84
ISSN: 2173-5786
DOI: 10.1016/j.acuroe.2015.01.002
Popis: Objectives To evaluate the oncological profile and risk of biochemical recurrence of patients with prostate cancer who underwent radical prostatectomy based on the time period in which the patients were operated. To evaluate the differences in prostate-specific antigen (PSA) at diagnosis of patients with or without biochemical recurrence based on these time periods. Material and methods Observation carried forward study of a cohort of 972 radical prostatectomies performed during three time periods (1994–2000, 2001–2006, 2007–2011). The importance of PSA at diagnosis on the time periods and on biochemical recurrence was assessed using a generalized linear model. The independent predictive behavior of biochemical recurrence was analyzed using Cox regression. Results The median follow-up was 38 (16–76) months. PSA levels at diagnosis were higher in the period 1994–2000 (12.97 ng/ml, p 0.001). The difference between PSA levels at diagnosis for the patients with or without biochemical recurrence was independent of the period (p = 0.84). The period during which surgery was performed was not an independent predictive factor for biochemical recurrence (p = 0.09). Conclusions Patients from the 2007–2011 period had less extracapsular disease in the radical prostatectomy. The period was not an independent predictive factor for biochemical recurrence.
Databáze: OpenAIRE
Externí odkaz: