| Popis: |
Men with loss-of-function (LOF) variants of toll-like receptor 7 (TLR7) are more susceptible to critical COVID-19. We aimed to determine the pathogenicity and binding affinity changes of TLR7 variants towards SARS-CoV2 RNA, MyD88, imiquimod, and N-acetylcysteine (NAC). TLR7 deleterious mutations increase the risk of critical COVID-19 by 16-folds (95% CI: 2.40–106.73, p = 0.005). LOF-TLR7 variants had impaired SARS COV-2 viral RNA sensing (-292.09 ± 11.86 Kcal/mol) compared to hypofunctional (-304.65 +/- 8.84 Kcal/mol), and neutral (-310.01 ± 5.29 Kcal/mol) TLR7 variants (p |
