Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin- Injected Rats: Post-Mortem Investigations
| Autor: | Abdullah Sener, Marie-Hélène Antoine, L Belkacemi, Ghalem Selselet-Attou, Joëlle Nortier, Emeline Hupkens, Willy Malaisse |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Kidney endocrine system diseases biology Glycogen business.industry medicine.disease Streptozotocin Proliferating cell nuclear antigen chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Diabetes mellitus Internal medicine Intermittent fasting biology.protein medicine Urea Glucose homeostasis business medicine.drug |
| Zdroj: | The Open Physiology Journal. 5:1-6 |
| ISSN: | 1874-3609 |
| DOI: | 10.2174/1874360920130702001 |
| Popis: | Intermittent fasting was previously reported to exert beneficial effects in sand rats, an animal model of diabetes. The present report complements recent comparable findings recorded in streptozotocin-induced diabetic rats (STZ rats). Intermittent fasting minimized the increase in pancreatic, hepatic and renal weight otherwise observed in the STZ rats. The glycogen content of the liver was higher in the STZ rats than in the control animals. It was positively correlated, at the individual level, with the hepatic glucose content. Significant positive correlations also prevailed between the plasma glucose concentration at sacrifice, which was lower in intermittently fasting or calorie-restricted STZ rats than in non- fasting STZ rats, and either the liver glucose content or liver total carbohydrate content. The kidney PCNA (proliferating cell nuclear antigen) index, as well as the plasma creatinine and urea concentrations, were also lower in intermittently fast- ing or calorie-restricted STZ rats than in non-fasting diabetic animals. These findings reinforce the view that intermittent fasting may exert a favourable effect, in terms of glucose homeostasis and the undesirable consequences of its perturba- tion, in diabetic animals. |
| Databáze: | OpenAIRE |
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