Effects of Retinoids in N-nitrosobis(2-oxopropy1)amine- Treated Hamsters
| Autor: | B. D. Roebuck, Thomas J. Curphey, Raymond K. Neff, Elna T. Kuhlmann, Daniel S. Longnecker |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Chemotherapy Hepatology Testicular atrophy Endocrinology Diabetes and Metabolism Incidence (epidemiology) medicine.medical_treatment Hamster medicine.disease chemistry.chemical_compound Endocrinology chemistry Nitrosamine Internal medicine Internal Medicine medicine Carcinoma Nitrosobis(2-oxopropyl)amine Carcinogen |
| Zdroj: | Pancreas. 1:224-231 |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/00006676-198605000-00005 |
| Popis: | The effect of feeding four synthetic retinoids was evaluated in carcinogen-treated hamsters. Syrian golden hamsters were injected with 20 mg/kg of N-nitrosobis(2-oxopropyl)amine (BOP) and then fed retinoid-supplemented diets for 39 weeks. All retinoid-treated groups grew more slowly than controls, and average survival was shorter in female retinoid-treated groups. A significant incidence of testicular atrophy was noted in male hamsters fed 2-hydroxyethylretinamide or 4-carboxyphenylretinamide. The incidence of pancreatic carcinomas was lower in 12 of 14 retinoid-fed groups than in the corresponding control groups, although the differences approached significance only in groups fed two of the retinoids--male hamsters fed N-4-propionyloxyphenylretinamide and those fed retinylidene dimedone. A low incidence of carcinoma in the control groups limits the conclusions that can be drawn from this study, but it is of note that there was no evidence of promotion. |
| Databáze: | OpenAIRE |
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