ChemInform Abstract: Synthesis and Biological Evaluation of 1,3,4-Triaryl-3-pyrrolin-2-ones, a New Class of Selective Cyclooxygenase-2 Inhibitors

Autor:	Carles Farrerons, Ana Fernandez‐Serrat, Joan Bosch, Juan‐Jesus Perez, Juan-Lorenzo Catena, Ignasi Miquel, Oriol Llorens, A.G. Fernández, Carmen Lagunas, Tomas Roca
Rok vydání:	2000
Předmět:	biology Chemistry General Medicine Combinatorial chemistry Pyrrole derivatives chemistry.chemical_compound Celecoxib medicine Lactam biology.protein Cyclooxygenase skin and connective tissue diseases Selectivity medicine.drug Biological evaluation
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200044128
Popis:	The synthesis and structure–activity relationships (SAR) of a series of novel selective COX-2 inhibitors are reported. The results show that some of the 1,3,4-triaryl-3-pyrrolin-2-ones 1 are more potent as COX-2 inhibitors than celecoxib, and that lactam 1d has the same selectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::66ee4acd2447a48fb127c2600ed74edf https://doi.org/10.1002/chin.200044128 Zobrazit plný text záznamu Plný text