Characterization of CD44-high memory phenotype T cells induced by enforced expression of the transcription factor PLZF (85.12)
| Autor: | Julia Raberger, Beatrice Grabner, Shinya Sakaguchi, Alexandra Schebesta, Nicole Boucheron, K. Emelie M. Blomberg, Anna Berglöf, Thomas Kolbe, Edvard Smith, Thomas Rülicke, Wilfried Ellmeier |
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| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 182:85.12-85.12 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | We and others have shown that transgenic expression of the transcription factor PLZF in the T cell lineage induces the appearance of CD44-high memory-phenotype (MP) T-cells (Savage et al. Immunity 2008; Raberger et al. PNAS, 2008). These MP T cells arise already in the thymus and produce IFNã upon PMA/ionomycin stimulation, thus sharing certain features with innate-like T cells. Furthermore, we observed that PLZF expression is up-regulated in Itk-deficient T cells, which are enriched with innate-like T cell subsets. To study the PLZF-induced MP T cell population in more detail, we are investigating whether these cells, like other innate-like T cells, are selected on classical or non-classical MHC molecules. Furthermore, PLZF transgenic mice are intercrossed with several knockout mice (e.g. Itk-/- or IL-15-/- mice) to determine signaling pathways/molecules required for their development and maintenance. Our studies will provide more insight into transcription pathways controlling the development of MP T cells with "innate-like" functions. Supported by the Austrian Science Fund FWF (SFB-F23, P19930). |
| Databáze: | OpenAIRE |
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