Bio- and Chemocatalysis for the Synthesis of Late Stage SAR-Enabling Intermediates for ROMK Inhibitors and MK-7145 for the Treatment of Hypertension and Heart Failure

Autor:	Ian Mangion, Rebecca T. Ruck, Fred J. Fleitz, Lushi Tan, Jongrock Kong, Qinghao Chen, Nelo R. Rivera
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Organic Chemistry Late stage Pharmacology 010402 general chemistry medicine.disease 01 natural sciences 0104 chemical sciences Heart failure ROMK medicine Physical and Theoretical Chemistry human activities
Zdroj:	Organic Process Research & Development. 25:405-410
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.0c00314
Popis:	A synthetic strategy to provide two late-stage intermediates for the synthesis of diverse analogues of ROMK inhibitors for the treatment of hypertension and heart failure is described. Key transfor...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::66dd86164e2d822771fedeea6a696007 https://doi.org/10.1021/acs.oprd.0c00314 Zobrazit plný text záznamu