Suitability of Fetal Tissues From Spontaneous Abortions and From Ectopic Pregnancies for Transplantation

Autor: Marijane Krohn, Qinyuan Low, Molly Hogan, Warren Kearney, Julie Mason, Beth Virnig, Takeshi Kondoh, F. Arthur Mcmorris, Jeanne Forbes, Michael McCormack, Kelly Feil, Tom Gasser, Alberto Hayek, Janice L. B. Byrne, Catherine Palmer, Beth Mueller, Sonny K. Chong, Raj Kapur, Bruce Blazer, Delbert H. Dayton, Sandy Maynard, Mark Hirschel, Peter D'ascoli, Soe Soe Thwin, Kathy Weese, Lillie Mae Padilla, Lee Ducat, Jeff Miller, John Q. Trojanowski, John P. Conrad, Anne Peterson, Kenneth Ward, Virginia Lee, Sharon Bledsoe, Ted Rigley, Judy Christianson, Bryan E. Hainline, Alan Fantel, Kathy Leppig, Catherine Verfaillie, D. Ware Branch, Susan Shen Schwarz, Jeff Blount, Ted Eastlund, Takashi Okagaki, Feng C. Zhou, Beverly Norris, Walter C. Low, Ying Jie, Helen Newman Gage, Stephen A. Heifetz, Preston Williams, Sharon Hillier, Yung Hsiao Chiang, Debra Kahlenbeck, Thomas Norwood, Daniel Peavy, Tara Vick, Ranjita Sengupta, Thomas J. Gill, Laura Coultrip, Lisa Pundt, Gayl Chrysler
Rok vydání: 1995
Předmět:
Zdroj: JAMA: The Journal of the American Medical Association. 273:66
ISSN: 0098-7484
DOI: 10.1001/jama.1995.03520250082038
Popis: Objective. —To assess the potential availability and utility of fetal tissues obtained from spontaneous abortions and from ectopic pregnancies for human transplantation therapy. Design. —Tissue collection and analysis by personnel skilled in tissue banking. Setting. —Procurement programs in five tissue banks located in diverse geographical areas that are funded by the National Institutes of Health. Patients. —All women entering obstetric clinics during 1993 who consented to participate in the study. Interventions. —None. Main Outcome Measures. —Evaluation of the products of conception by standard developmental, histological, microbiological, and cytogenetic criteria. Results. —From 22235 obstetric admissions, 1250 spontaneously aborted embryos and 247 products of ectopic pregnancies were obtained. Of these, seven embryos (0.5%) were potentially useful for human transplantation therapy. Conclusion. —Fetal tissues from spontaneous abortions and from ectopic pregnancies are quite limited as feasible sources for human transplantation therapy. ( JAMA . 1995;273:66-68)
Databáze: OpenAIRE