Epidemiology and association rules analysis for pulmonary tuberculosis cases with extrapulmonary tuberculosis from age and gender perspective: a large-scale multi-center observational study in China
| Autor: | Peilan Zong, Ling Chen, Mingwu Li, Yan-mei Feng, Xinjie Li, Jian Zheng, Peijun Tang, Yunqing Chang, Jingmin Qin, Jianyong Zhang, Pu Wang, Hongyan Chen, Yang Li, Hongwei Liu, Jianxiong Liu, Wei Shu, Shenjie Tang, Lei Wu, Liang Li, Qingyao Xie, Xiaohong Chen, Dawei Chen, Yongkang Dong, Chao Zheng, Wenge Han, Meiying Wu, Yingrong Du, Lei Tan, Shuliang Guo, Yuanyuan Li, Qiang Song, Zaoxian Mei, Wenyu Cui, Qunyi Deng, Kun Yan, Mei Yang, Dan Lei, Quanhong Wang, Zhiyi Yang, Jian Zhang, Wenyu Liu, Xinghua Shen, Wanli Kang, Jinshan Ma, Tong Ren, Xiangyang Yao, Xiaofeng Yan, Yi Zhang, Fenglin Liu, Junfeng Han, Yanli Zhang, Xinguo Zhao, Song Yang, Yuanyuan Liu, Jian Du, Ertai A, Fujian Li |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty integumentary system Association rule learning business.industry Extrapulmonary tuberculosis Perspective (graphical) macromolecular substances environment and public health Pulmonary tuberculosis Scale (social sciences) Epidemiology Medicine Observational study business China |
| Popis: | Background Tuberculosis (TB), a multi-systemic disease with protean presentation, remains a major global health problem. Although concurrent pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) cases are commonly observed clinically, knowledge regarding concurrent PTB-EPTB is limited. Here a large-scale multi- center observational study conducted in China aimed to study epidemiology of concurrent PTB-EPTB cases by diagnostically defining TB types then implementing association rules analysis.Methods This study was conducted at 21 hospitals in 15 provinces in China and included all inpatients with confirmed TB diagnoses admitted from Jan 2011 to Dec 2017. Association rules analysis was conducted for cases with concurrent PTB and various types of EPTB using the Apriori algorithm. Results Evaluation of 438,979 TB inpatients indicated PTB was the most commonly diagnosed (82.05%) followed by tuberculous pleurisy (23.62%). Concurrent PTB- EPTB was found in 129,422 cases (29.48%) of which tuberculous pleurisy was the most common concurrent EPTB type observed. Fully adjusted multivariable logistic regression models demonstrated that odds ratios of concurrent PTB-EPTB cases varied by gender and age group. For PTB cases with concurrent EPTB, the strongest association was found between PTB and concurrent bronchial tuberculosis (lift=1.09). For EPTB cases with concurrent PTB, the strongest association was found between pharyngeal/laryngeal tuberculosis and concurrent PTB (lift=1.11).Confidence and lift values of concurrent PTB-EPTB cases varied with gender and age.Conclusions Numerous concurrent PTB-EPTB case types were observed, with confidence and lift values varying with gender and age. Clinicians should screen for concurrent PTB- EPTB in order to improve treatment outcomes. |
| Databáze: | OpenAIRE |
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