Regioselective catalytic alkylation ofN-heterocycles in continuous flow
| Autor: | László Kocsis, Ferenc Darvas, Gellért Sipos, György Dormán, László Lengyel, Tamás Sipőcz, Richard V. Jones |
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| Rok vydání: | 2016 |
| Předmět: |
Fluid Flow and Transfer Processes
Indole test 010405 organic chemistry Chemistry Organic Chemistry Regioselectivity Flow chemistry Alkylation 010402 general chemistry 01 natural sciences 0104 chemical sciences Catalysis Chemistry (miscellaneous) Atom economy Yield (chemistry) Organic chemistry Selectivity |
| Zdroj: | Journal of Flow Chemistry. 6:117-122 |
| ISSN: | 2063-0212 2062-249X |
| DOI: | 10.1556/1846.2015.00030 |
| Popis: | A novel method for C–H functionalization of heteroaromatic rings by using continuous-flow reactors is reported. Direct alkylation reactions were investigated under heterogeneous catalytic conditions using simple transition metal catalysts at elevated temperature and pressure. As a model reaction, the alkylation of indole was attempted using cheap Raney® Nickel catalyst. Alcohols served both as alkylating agent and as reaction media. The targeted 3-alkyl-indoles were obtained in moderate to good yield with reasonable selectivity. Transient protection on the N-atom increased the selectivity up to 80%. The scope and limitations were also investigated. In summary, direct alkylation with alcohols represents a rapid (residence time of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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