Biochemical Investigation of Some Proteins from Human Primary Teeth to Evaluate Heavy Metal Pollution
| Autor: | D. Iordǎchescu, Cristina M. Ciofrangeanu, Bianca Galateanu, Stef Manea, Anisoara Cimpean, R. Ciubar Ion |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Molar
Remineralisation Materials science Mechanical Engineering Metallurgy Gelatin Zymography Microbiology Extracellular matrix stomatognathic diseases medicine.anatomical_structure stomatognathic system Mechanics of Materials Carious teeth Dentin medicine Collagenase Alkaline phosphatase General Materials Science medicine.drug |
| Zdroj: | Key Engineering Materials. 415:53-56 |
| ISSN: | 1662-9795 |
| DOI: | 10.4028/www.scientific.net/kem.415.53 |
| Popis: | This investigation is based on the premise that heavy metals are sequestered by the mineral phase of teeth [1,2], hydroxyapatite, during their formation and there is a relation between heavy metal pollution and progressive destruction of human primary tooth. Our study was carried out on temporary molars – sound and carious - extracted from children up to 6 year old, residing in an area of Romania known to be highly polluted with heavy metals (Pb and Cd). In carious dentin extracts we found increased levels of collagen type 1 and alkaline phosphatase activity that can be correlated with the remineralization processus during teeth decay. Gelatin zymography shown increased MMP-1 (type-I collagenase) and MMP-2 (gelatinase-A) activities only in dentin extract from carious teeth isolated from children residing in a highly polluted area, suggesting their role in pathological extracellular matrix (ECM) remodeling and degradation processes in the progression of carious decay. |
| Databáze: | OpenAIRE |
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