FcγRIIA and IIIA polymorphisms predict clinical outcome of trastuzumab-treated metastatic gastric cancer
| Autor: | Niu Wang, Xiao Li Wei, Yun Xin Lu, De Shen Wang, Miao Zhen Qiu, Feng Hua Wang, Yu Hong Li, Zhi Qiang Wang, Si mei Shi, Rong jiao Wang, Rui-Hua Xu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Antibody-dependent cell-mediated cytotoxicity Chemotherapy medicine.medical_specialty business.industry medicine.medical_treatment Hazard ratio Metastatic gastric cancer 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Fluorouracil Trastuzumab 030220 oncology & carcinogenesis Internal medicine Genotype medicine Pharmacology (medical) In patient business medicine.drug |
| Zdroj: | OncoTargets and Therapy. 10:5065-5076 |
| ISSN: | 1178-6930 |
| Popis: | Trastuzumab has substantial antitumor activity in metastatic gastric cancer. One such mechanism by which it exerts its antitumor activity is antibody-dependent cell-mediated cytotoxicity, which has been reported to be influenced by FcγRIIA and IIIA polymorphisms. This study is the first to assess their impact on trastuzumab efficacy in patients with metastatic gastric cancer. We retrospectively examined 42 Her-2-positive patients receiving fluorouracil and platinum-based chemotherapy and trastuzumab, and 68 Her-2-negative patients receiving fluorouracil and platinum-based chemotherapy only as the first-line treatment. FcγRIIA and IIIA polymorphisms were assessed, and their associations with efficacy in both settings were analyzed. In patients treated with trastuzumab, the FcγRIIA H/H genotype was associated with significantly superior progression-free survival (PFS) (hazard ratio [HR] [95% CI]: 0.36 [0.16-0.82], adjusted HR [95% CI]: 0.18 [0.07-0.48], P=0.001). When combining FcγRIIA and IIIA polymorphisms, the FcγRIIA H/H or FcγRIIIA V/V genotype was associated with a significantly improved disease control rate (P=0.04) and PFS (HR [95% CI]: 0.29 [0.13-0.67], adjusted HR [95% CI]: 0.17 [0.07-0.45], P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|