Alendronate-related oral mucosa ulcerations
| Autor: | Miguel Ángel González-Moles, Jose V Bagán-Sebastián |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Drug
Cancer Research medicine.medical_specialty Bone disease business.industry Alendronic acid media_common.quotation_subject Osteoporosis medicine.disease Dermatology Pathology and Forensic Medicine Surgery medicine.anatomical_structure Otorhinolaryngology medicine Periodontics Oral Surgery Oral mucosa Adverse effect business Complication Adverse drug reaction medicine.drug media_common |
| Zdroj: | Journal of Oral Pathology & Medicine. 29:514-518 |
| ISSN: | 0904-2512 |
| DOI: | 10.1034/j.1600-0714.2000.291006.x |
| Popis: | Alendronate is widely used in the treatment of osteoporosis and other bone diseases. Although it is considered a well-tolerated drug, there are numerous reports of adverse effects on the mucosa in the upper aerodigestive tract, with oesophagitis as the most common complication. The strict regulations for the proper administration of the drug indicate that these side effects might well be the result of a direct, irritant mechanism on the upper aerodigestive tract. We present two clinical cases of patients who developed extensive palatal ulcers as a result of taking alendronate. We discuss possible mechanisms implicated in the production of the ulcers and some clinical factors of interest. |
| Databáze: | OpenAIRE |
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