Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu

Autor:	Felix Tritschler, Elisa Izaurralde, Eric Huntzinger
Rok vydání:	2010
Předmět:	Genetics PABPC1 microRNA Gene silencing Translation (biology) Cell Biology Plasma protein binding MRNA stabilization Biology Argonaute Molecular Biology Poly(A)-Binding Protein I Cell biology
Zdroj:	Nature Reviews Molecular Cell Biology. 11:379-384
ISSN:	1471-0080 1471-0072
Popis:	GW182 proteins have emerged as key components of microRNA (miRNA) silencing complexes in animals. Although the precise molecular function of GW182 proteins is not fully understood, new findings indicate that they act as poly(A)-binding protein (PABP)-interacting proteins (PAIPs) that promote gene silencing, at least in part, by interfering with cytoplasmic PABP1 (PABPC1) function during translation and mRNA stabilization. This recent discovery paves the way for future studies of miRNA silencing mechanisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::669bfbac34ab90918d5e64a215770636 https://doi.org/10.1038/nrm2885 Zobrazit plný text záznamu Plný text ve formátu PDF