| Autor: | Hans Vallin, Börje Darpö, Harry Jgm Crijns, Per Blomström, Birgitta Houltz, Johannes Brachmann, Elisabeth Svernhage, Steen M Jensen, Karl Swedberg, Nils Edvardsson |
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| Rok vydání: | 1999 |
| Předmět: |
Pharmacology
Fibrillation medicine.medical_specialty Heart disease business.industry medicine.medical_treatment Torsades de pointes Atrial fibrillation General Medicine Antiarrhythmic agent medicine.disease Cardioversion chemistry.chemical_compound chemistry Anesthesia Internal medicine Cardiology Medicine Almokalant Pharmacology (medical) Sinus rhythm medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular Drugs and Therapy. 13:329-338 |
| ISSN: | 0920-3206 |
| DOI: | 10.1023/a:1007759500274 |
| Popis: | Purpose: To assess the efficacy of the I-kr-blocker almokalant attempting to convert chronic atrial tachyarrhythmias, and to find predictors of conversion, to sinus rhythm. Methods: The electrophysiological effects of a 6-hour infusion of almokalant, to a total dose of 25 +/- 4 mg, were assessed by ECG and transesophageal atrial electrograms (TAE) in 100 consecutive patients with atrial fibrillation / flutter (n = 95 / 5) of 8 +/- 12 months' duration (range 1 to 99 months). Results: The conversion rate was 32%. The time to conversion was 3.5 +/- 2.2 hours. During infusion increases in QT(top) (292 +/- 35 to 335 +/- 44 ms, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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