Strategies for developing carbohydrates as glycoside hydrolase inhibitors

Autor:	Sunayana Kapil, Radhika Thanvi, Steven J. Sucheck
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Enzyme chemistry Biochemistry Glycoside Hydrolase Inhibitors Glycoconjugate Miglitol medicine Glycoside hydrolase Glycosidic bond Genome medicine.drug Acarbose
DOI:	10.1039/9781788013864-00207
Popis:	The cleavage of the glycosidic bond in glycoconjugates is an important activity in biological systems. The enzymes catalyzing this activity are termed as “glycoside hydrolases” (GH). About 1% of the genome in organisms are encoded by GHs. Researchers have put in tremendous amount of effort in understanding the mechanism of GHs and the effect of their function on chronic diseases such as tuberculosis and diabetes. A variety of therapeutics such as Acarbose and Miglitol have been developed based on these studies which pave the way for further development in the field. This chapter focuses on different strategies that can be considered for designing carbohydrates as potential inhibitors of glycoside hydrolases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::667fa41f55e79eec4560e5b2384b3d2c https://doi.org/10.1039/9781788013864-00207 Zobrazit plný text záznamu