Preparation of enantiopure sultams by intramolecular Diels–Alder reaction of furan-containing vinylsulfonamides

Autor:	Birgit Wibbeling, Viktor O. Rogatchov, Peter Metz, Pia Schwab, Roland Fröhlich, Heiko Bernsmann
Rok vydání:	2002
Předmět:	chemistry.chemical_compound Enantiopure drug Chemistry High pressure Furan Intramolecular force Organic Chemistry Drug Discovery Organic chemistry Biochemistry Cycloaddition Diels–Alder reaction
Zdroj:	Tetrahedron Letters. 43:4753-4756
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(02)00912-7
Popis:	Enantiomerically pure δ- and γ-sultams have been prepared by intramolecular [4+2] cycloaddition of N-1-phenylethyl substituted vinylsulfonamides with purely thermal activation and under high pressure. An optimized procedure for reductive debenzylation of the resultant δ-sultams is also reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::667ca46362e01c8daac13fcd5fafa964 https://doi.org/10.1016/s0040-4039(02)00912-7 Zobrazit plný text záznamu Full Text from ScienceDirect