Radiation sterilization of medicinal formulations of doxorubicin bound to poly(butylcyanoacrylate) nanoparticles

Autor:	É. G. Tushov, Olga Maksimenko, A. A. Molin, Yu. V. Stukalov, Svetlana Gelperina, Joerg Kreuter, T. N. Prudskova, E.P. Pavlov, P. G. Sveshnikov
Rok vydání:	2008
Předmět:	Pharmacology chemistry.chemical_classification Chemistry Chemical structure Nanoparticle Polymer Toxicology Colloid Drug Discovery medicine Radiation Sterilization Doxorubicin Irradiation medicine.drug Nuclear chemistry Gamma irradiation
Zdroj:	Pharmaceutical Chemistry Journal. 42:363-367
ISSN:	1573-9031 0091-150X
Popis:	Polybutylcyanoacrylate nanoparticles represent a potential system for delivering medicinal agents. The present report describes development of a method for radiation sterilization of medicinal formulations of doxorubicin based on polybutylcyanoacrylate nanoparticles. The physicochemical properties of the medicinal formulation were studied after gamma irradiation and irradiation with accelerated electrons over the dose range 10–35 kGy. The chemical structure of doxorubicin and the polymer carrier was found to be intact after irradiation at a dose of 25 kGy. Irradiation at these doses also had no effect on the colloidal properties of polymer nanoparticles, which retained their stability to aggregation and sedimentation. The optimum sterilizing dose was 15 kGy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::667c9b2bdc1e620132475ca00eb60e06 https://doi.org/10.1007/s11094-008-0128-4 Zobrazit plný text záznamu Plný text ve formátu PDF