Comparative Bioactive Properties of Bivalve Clams Against Different Disease Molecular Targets

Autor:	Minju Joy, Kajal Chakraborty, Vijayagopal Pananghat
Rok vydání:	2016
Předmět:	0301 basic medicine Pharmacology Antioxidant medicine.medical_treatment Biophysics 04 agricultural and veterinary sciences Cell Biology Biology 040401 food science Toxicology 03 medical and health sciences Villorita cyprinoides 030104 developmental biology 0404 agricultural biotechnology Functional food Molecular targets medicine Potential source Food science Paphia malabarica Food Science
Zdroj:	Journal of Food Biochemistry. 40:593-602
ISSN:	0145-8884
DOI:	10.1111/jfbc.12256
Popis:	Clams occupy a predominant share of the edible bivalve mollusks in the coastal regions, and are important seafood resources. Antioxidant, anti-diabetic, anti-inflammatory and antihypertensive potential of ethyl acetate-methanol (EtOAc-MeOH) extract of bivalve clams, Villorita cyprinoides and Paphia malabarica were evaluated using various in vitro systems. EtOAc-MeOH fraction of P. malabarica demonstrated greater 1, 1-diphenyl-2-picryl-hydrazil (0.76 mg/mL) and 2, 2′-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid (1.27 mg/mL) radical scavenging ability. A greater anti-ACE, anti-COX-2/5-LOX properties (1.11, 0.92 and 1.51 mg/mL, respectively), along with DPP-IV (1.00 mg/mL) and α-glucosidase (1.47 mg/mL) inhibitory activities were recorded in the EtOAc-MeOH fraction of P. malabarica than V. cyprinoides. A significant co-linearity was found between various bioactive properties and the down-fielded electronegative groups present in the 1H-NMR spectra of the crude EtOAc-MeOH fractions of bivalve clams. The current findings showed the importance of the bivalves as potential source of antioxidative leads for use as functional food supplements to combat oxidative stress-induced diseases. Practical Applications The edible bivalve clams, V. cyprinoides and P. malabarica are broadly available in the coastal regions of India and demonstrated to possess a number of bioactivities against different disease targets induced by free radical formation. The EtOAc-MeOH fractions obtained from these bivalve clams recorded the COX-1 and COX-2 ratio of greater than 2.0 compared with NSAIDs (
Databáze:	OpenAIRE
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