| Popis: |
The kinetics and mechanism of oxidation of cetirizine hydrochloride by Mn(VII) in acidic medium was studied spectrophotometrically. The electron transfer reaction between MnO 4 - and the drug have been studied over the range 2.0 ? 10 3 [cetirizine hydrochloride] ? 6.0, 2.5 ? pH ? 4.5 and 295 K ? T ? 313 K in aqueous medium. The electron transfer reaction shows first order dependence in [MnO 4 - ] T and [cetirizine hydrochloride]. The rate of the reaction was found to increase with increasing pH of the medium. The conjugate base of the reactant drug and MnO 4 - reacts to produce products. The activation parameters ?H ? (kJ mol -1 ) and ?S ? (JK -1 mol -1 ) for the electron transfer reaction was found to be 33.93 and -143.00. The product of the reaction was cetirizine N-oxide. Keywords : Cetirizine, Oxidation, Kinetics, Cetirizine N-Oxide, Spectrophotometer. |
