1H magnetic resonance spectroscopy of the brains of normal infants and after perinatal hypoxia-ischemia
| Autor: | Ernest B. Cady, Juliet Penrice, Marzena Wylezinska, John S. Wyatt, Raymond F. Reynolds, RF Aldridge, E. Osmund, A Lorek |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Poor prognosis Radiological and Ultrasound Technology business.industry Metabolite Perinatal hypoxia Biophysics Ischemia Nuclear magnetic resonance spectroscopy Creatine medicine.disease Phosphocreatine chemistry.chemical_compound Endocrinology nervous system chemistry Internal medicine Anesthesia Medicine Gestation Radiology Nuclear Medicine and imaging business |
| Zdroj: | Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine. 2:353-355 |
| ISSN: | 1352-8661 |
| Popis: | The aims of this study were to define proton (1H) metabolite peak-area ratios in the brains of normal infants and to investigate abnormalities after perinatal hypoxia-ischemia. Point-resolved spectroscopy (PRESS) data were collected at 2.4 T with an echo time (TE) of 270 ms from 8-ml voxels located in the thalamus or occipito-parietal region. Fourteen normal and 9 asphyxiated infants were studied. The gestational plus postnatal ages (GPA) of these two groups were 31–41 (median 36) and 27–41 (37) weeks, respectively, and the asphyxiated infants were studied aged 0–10 (2) days. Peak-area ratios were determined in the normal infants for choline-containing compounds (Cho), creatine plus phosphocreatine (Cr),N-acetylaspartate (NAA) and lactate (Lac). Lactate was detected in all the normal infants and Lac/NAA was higher in the occipito-parietal region than in the thalamus (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink