Genome-wide Association Study Meta-analysis of Blood Pressure Traits and Hypertension in Sub-Saharan African Populations: An AWI-Gen Study

Autor: Surina Singh, Ananyo Choudhury, Scott Hazelhurst, Nigel Crowther, Palwende Boua, Hermann Sorgho, Godfred Agongo, Engelbert Nonterah, Lisa Micklesfield, Shane Norris, Isaac Kisiangani, Shukri Mohamed, Francesc Gomez-Olive, Stephen Tollman, Solomon Choma, Jean-Tristan Brandenburg, Michele Ramsay
Rok vydání: 2023
DOI: 10.21203/rs.3.rs-2532794/v1
Popis: Most hypertension-related genome-wide association studies (GWAS) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure-related traits (systolic and diastolic blood pressure, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N=10,775), identified two genome-wide significant signals (p
Databáze: OpenAIRE