Synthesis of 8-Oxoberbines and Related Benzolactams by Pd(OAc)2-Catalyzed Direct Aromatic Carbonylation

Autor:	Masao Tokuda, Mamoru Miyazawa, Takeshi Ohkuma, Hisanori Senboku, Kazuhiko Orito, Yu Onozaki, Takatoshi Nakamura, Akiyoshi Horibata, Nobuhito Kurono, Takashi Tokuhashi
Rok vydání:	2013
Předmět:	Chemistry Site selectivity Organic Chemistry Organic chemistry Carbonylation Medicinal chemistry Catalysis
Zdroj:	Journal of Heterocyclic Chemistry. 50:E48-E54
ISSN:	0022-152X
DOI:	10.1002/jhet.1044
Popis:	A variety of alkoxy-substituted benzolactams with a berbine or yohimbane skeleton were prepared from 1-benzyl-1,2,3,4-tetrahydroisoquinolines or 1-benzyl-1,2,3,4-tetrahydro-β-carbolines by a phosphine-free Pd(II)-catalyzed direct aromatic carbonylation in a Pd(OAc)2-Cu(OAc)2 catalytic system. The site selectivity was compared with that of the carbonylation with Pd(OAc)2 or Pd(OAc)2·2 PPh3, respectively.
Databáze:	OpenAIRE
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