The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data
| Autor: | Liliana Lacramioara Pavel, Liliana Tartau, Gratiela Eliza Popa, Catalina Elena Lupusoru, Ciprian Rezus, Cristiana Filip, Alina Panainte, Maria Bogdan, Alin Constantin Pinzariu, Beatrice Rozalina Buca, Raoul Vasile Lupusoru, Elena Rezus |
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| Rok vydání: | 2018 |
| Předmět: |
Materials Science (miscellaneous)
Process Chemistry and Technology General Engineering Inflammation General Chemistry General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Nitric oxide chemistry.chemical_compound chemistry Materials Chemistry medicine General Pharmacology Toxicology and Pharmaceutics medicine.symptom |
| Zdroj: | Revista de Chimie. 69:2899-2903 |
| ISSN: | 2668-8212 0034-7752 |
| DOI: | 10.37358/rc.18.10.6649 |
| Popis: | We aimed to investigate the effects of two nitric oxide donors in acute inflammation in rats. The experiment was carried out on white Wistar rats, randomly distributed in 4 groups of 5 animals each; the substances were administered intraperitoneally as follows: Group 1 (SS): saline solution 0.1mL/100 g body weight (control); Group 2 (IND): indometacin 150 mg/kg body weight; Group 3 (NEB): nebivolol 1 mg/kg body weight; Group 4 (GSNO): S-nitroso-glutathione 1 mg/kg body weight. An experimental model of acute hind paw inflammation with carrageenan was used for the researches. The influence of the nitric oxide donors on blood parameters, specific inflammatory and immune markers was evaluated 24 h, respectively 72 hours after the injection of irritant agent. The experimental protocol was implemented according to the recommendations of our University Committee for Research and Ethical Issues. The administration of nitric oxide donors nebivolol and S-nitroso-glutathione was accompanied by a substantial diminution of paw edema, as well as by an important decrease in the percent of lymphocytes, a reduction of interleukin 6 and tumor necrosis factor alpha values. The effects of nebivolol were more accentuated than of S-nitroso-glutathione, but less intense than of indomethacin in the experiment. The treatment with nebivolol and S-nitroso-glutathione produced anti-inflammatory effects on local acute inflammation in the carrageenan-induced paw edema test in rats. |
| Databáze: | OpenAIRE |
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