Goserelin (Zoladex ) depot in the treatment of endometriosis
| Autor: | Romeo P. Reichel, Karl-W. Schweppe, null Zoladex Endometriosis Study Group |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Medical treatment medicine.diagnostic_test business.industry medicine.drug_class Depot Goserelin Endometriosis Hypoestrogenism Obstetrics and Gynecology medicine.disease Surgery Discontinuation Reproductive Medicine Gonadotropin-releasing hormone agonist medicine business Laparoscopy medicine.drug |
| Zdroj: | Fertility and Sterility. 57:1197-1202 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)55073-0 |
| Popis: | Study Objective To evaluate the safety and efficacy of Goserelin (Zoladex depot; ICI Pharmaceuticals, Macclesfield, Cheshire, United Kingdom) in the treatment of endometriosis. Design Open study. Setting Eleven centers in Germany and 1 center in Austria. Patients One hundred forty-six patients with pelvic endometriosis. Intervention Goserelin (Zoladex depot) therapy, one depot (3.6 mg) subcutaneously every 4 weeks for 6 months. Results Total subjective score and total pelvic symptom score showed a reduction by 86% and 93%, respectively, at the end of the treatment and did not exceed one fifth of the pretreatment value throughout the follow-up period of 48 weeks. One hundred seven women underwent a second laparoscopy at the end of the therapy for determination of objective efficacy: 54% of the patients showed a reduction of implants and adhesions by at least 50% or more, and 31.5% had a complete resolution of visible deposits. The mean reduction of implants and adhesions was 50%, and the mean reduction of implants 72%. Twenty of 64 (31.3%) previously infertile patients successfully conceived within 12 months after discontinuation of the therapy. Goserelin led to a down regulation of the pituitary ovarian axis and as a pharmacological effect of this hypoestrogenism most patients had hot flushes and vaginal dryness. Conclusions Zoladex depot therapy proved to be safe and effective in the medical treatment of endometriosis. |
| Databáze: | OpenAIRE |
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