Investigation of Cerebral Autoregulation in the Newborn Piglet During Anaesthesia and Surgery
| Autor: | Jane Hassell, G Kawano, Nicola J. Robertson, Kevin D. Broad, Gemma Bale, I Fierens, Ilias Tachtsidis, Robert D. Sanders, Gennadij Raivich, Aaron Oliver-Taylor, Jamshid Rostami |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Programmed cell death Exacerbation business.industry Histology Oxygenation Cerebral autoregulation 3. Good health Surgery 03 medical and health sciences 0302 clinical medicine Blood pressure Isoflurane Apoptosis 030225 pediatrics Anesthesia Medicine 030212 general & internal medicine business medicine.drug |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9781493905836 |
| DOI: | 10.1007/978-1-4939-0620-8_22 |
| Popis: | The relationship between cerebral autoregulation (CA) and the neurotoxic effects of anaesthesia with and without surgery is investigated. Newborn piglets were randomly assigned to receive either 6 h of anaesthesia (isoflurane) or the same with an additional hour of minor surgery. The effect of the spontaneous changes in mean arterial blood pressure (MABP) on the cerebral haemodynamics (oxy- and deoxy-haemoglobin, HbO2 and Hb) was measured using transverse broadband near-infrared spectroscopy (NIRS). A marker for impaired CA, concordance between MABP and intravascular oxygenation (HbD = HbO2 − Hb) in the ultra-low frequency domain (0.0018–0.0083 Hz), was assessed using coherence analysis. Presence of CA impairment was not significant but found to increase with surgical exacerbation. The impairment did not correlate with histological outcome (presence of cell death, apoptosis and microglial activation in the brain). |
| Databáze: | OpenAIRE |
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