The Efficacy and Safety of Yokukansankachimpihange for Treating Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: An Open-Label Pilot Study
| Autor: | Mizuki Oka, Ryutaro Arita, Hajime Tabuchi, Takahito Yoshizaki, Kei Funaki, Takuya Hamaguchi, Kenji Watanabe, Masaru Mimura, Tetsuhiro Yoshino, Kaori Sawai, Yuko Horiba, Miwako Ohgishi |
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| Rok vydání: | 2018 |
| Předmět: |
Mini–Mental State Examination
030214 geriatrics medicine.diagnostic_test business.industry Yokukansan General Medicine Caregiver burden medicine.disease Irritability 03 medical and health sciences 0302 clinical medicine Rating scale Medicine Dementia Anxiety Apathy medicine.symptom business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Advances in Alzheimer's Disease. :141-152 |
| ISSN: | 2169-2467 2169-2459 |
| Popis: | Previous clinical trials have demonstrated the efficacy of yokukansan, a traditional Japanese medicine, for the treatment of behavioral and psychological symptoms of dementia (BPSD). However, less evidence is available for the treatment of BPSD with yokukansankachimpihange (YKSCH), which consists of yokukansan and two additional herbal ingredients. The present study was conducted to investigate the efficacy and safety of YKSCH for treating BPSD in patients with Alzheimer’s disease (AD). We enrolled outpatients with mild-to-moderate AD who exhibited BPSD and obtained a Neuropsychiatric Inventory (NPI) score of >3 including subscale scores for “agitation”, “anxiety”, “irritability”, and “sleep and night-time behavior change”. A daily YKSCH dose of 7.5 g was administered for 12 weeks with concomitant administration of anti-dementia medication. BPSD was evaluated using the NPI at baseline and every 4 weeks during the intervention. We also examined apathy using the Japanese translation of the Apathy Scale, the short version of the Japanese version of the Zarit Caregiver Burden Interview, and the Modified Crichton Rating Scale for Predicting Activities of Daily Living. Cognitive dysfunction was evaluated using the Mini Mental State Examination and the AD Assessment Scale-Cognitive (Japanese version). Five participants were enrolled. The NPI total score tended to decrease between the baseline and 8-week evaluations during the YKSCH intervention (Wilcoxon signed rank test, P = 0.063). In terms of the NPI subscale scores, “apathy”, “agitation”, “delusions”, and “sleep and night-time behavior change” decreased after the intervention in those who exhibited each symptom at baseline. There were no significant differences in the other scores examined. No serious adverse events were observed. YKSCH could ameliorate BPSD in patients with mild-to-moderate AD with agitation, anxiety, irritability, and sleep and night-time behavior change, and it was well-tolerated. |
| Databáze: | OpenAIRE |
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