SYNTHESIS, CHARACTERIZATION, ANTIOXIDENT AND ANTICANCER HUMAN STUDIES OF NEW METAL ION COMPLEXES OF POLY SCHIFF BASE DERIVED FROM 4-AMINOACETOPHENONE WITH SALICYLALDEHYDE AND 4-BROMOANILINE
| Autor: | Tamara Q.m Al-sahlanee, Mohammed Ha Al-amery |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Schiff base biology 010405 organic chemistry Ligand Pharmaceutical Science Molar conductivity 010402 general chemistry biology.organism_classification 01 natural sciences 0104 chemical sciences HeLa Metal chemistry.chemical_compound chemistry Salicylaldehyde visual_art Mass spectrum visual_art.visual_art_medium Pharmacology (medical) Reactivity (chemistry) Nuclear chemistry |
| Zdroj: | Asian Journal of Pharmaceutical and Clinical Research. 11:489 |
| ISSN: | 2455-3891 0974-2441 |
| Popis: | Objective: New metal ion complexes of some transition metal ions [Cu(II), Cr(III), Cd(II), Zn(II), and VO(II)] of prepared ligand 2-(((4-(1-((4-bromophenyl) imino)ethyl) phenyl) imino) methyl) phenol were synthesized.Methods: The method is based on Schiff bases reaction of 4-aminoacetophenone with salicylaldehyde and P-bromoaniline.Results: The structures of the new metal ion complexes were characterized by elemental microanalysis (C.H.N), Fourier transform infrared, ultra violet-visible spectra, thermal gravimetric analysis-differential thermal gravimetric, flame atomic absorption, molar conductivity, magnetic susceptibility measurement, and mass spectra. According to the obtained data, the probable coordination geometries of these complexes were suggested as octahedral excepted C5 was pyramidal. All complexes were found to be non-electrolyte.Conclusion: The anticancer activity was screened against human cancer cell such brain cancer cells (AMJM), cervical cancer cells (HeLa), ovarian cancer cells (SKOV-3), and breast cancer cells (MCF-7). The results indicate that the metal ion complexes show increase cytotoxicity in proliferation to cell lines as compared to the free ligand. Antioxidant activities were shown the ligand, and their complexes have high reactivity. |
| Databáze: | OpenAIRE |
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