Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Steady-State Sickle Cell Disease Children at University of Ilorin Teaching Hospital, Ilorin
| Autor: | Surajudeen Oyekunle Ogunkanbi, Olanrewaju T. Adedoyin, SK Ernest, Sikiru Abayomi Biliaminu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities education.field_of_study medicine.medical_specialty Red Cell business.industry Population Disease medicine.disease Teaching hospital hemic and lymphatic diseases Statistical significance Internal medicine Medicine Population study Analysis of variance business education Glucose-6-phosphate dehydrogenase deficiency |
| Zdroj: | Open Journal of Pediatrics. :29-38 |
| ISSN: | 2160-8776 2160-8741 |
| DOI: | 10.4236/ojped.2019.91004 |
| Popis: | Background: Both glucose-6-phosphate dehydrogenase (G6PD) deficiency and sickle cell disease (SCD) are prevalent in malaria-endemic regions. Controversy however persists as to whether G6PD deficiency is commoner in SCD subjects compared with the general population. Co-existence of the enzyme-deficient state with a chronic haemolytic disorder, like SCD, could potentially predispose to fatal haemolytic episodes. There is however a dearth of paediatric studies on this subject. Aims and Objectives: To determine the prevalence and demographic determinants of G6PD deficiency in children with SCD. Methods: Red cell G6PD activity was determined in 115 steady-state sickle cell disease children aged 0.5 - 17 years, in steady state and equal number of age & gender-matched non-SCD controls using the quantitative method. A measured G6PD activity of |
| Databáze: | OpenAIRE |
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