Metal-Free C(sp3)–H Amination of 2-Oxindoles in Water: Facile Synthesis of 3-Substituted 3-Aminooxindoles
| Autor: | Wen-Hui Bao, Huang Yiling, Le-Han Gao, Gan-Ping Chen, Wen-Ting Wei, Xu-Dong Xu, Wei-Ting Chen, Yi-Ning Wang, Wen-Ming Zhu |
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| Rok vydání: | 2018 |
| Předmět: |
Primary (chemistry)
010405 organic chemistry Renewable Energy Sustainability and the Environment Chemistry General Chemical Engineering Radical General Chemistry 010402 general chemistry 01 natural sciences Environmentally friendly Combinatorial chemistry 0104 chemical sciences Coupling (electronics) Metal free Environmental Chemistry Amination |
| Zdroj: | ACS Sustainable Chemistry & Engineering. 6:5615-5619 |
| ISSN: | 2168-0485 |
| Popis: | A novel metal-free C(sp3)–H amination of 2-oxindoles with alkylamines to afford C–N coupling products under mild conditions has been exploited. A series of 3-substituted 2-oxindoles and primary/secondary amines substrates were found to be well tolerated, affording the corresponding 3-substituted 3-aminooxindoles in 43%–92% yields. This method uses the economical and environmentally friendly “I2–TBHP” system, and the mechanistic studies revealed that the procedure undergoes through a radical pathway. |
| Databáze: | OpenAIRE |
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