A fluorescent photosensitizer with far red/near-infrared aggregation-induced emission for imaging and photodynamic killing of bacteria
| Autor: | Yunmeng Zhang, Lianjie Zhu, Xiaowei Zhao, Qiusheng Wang, Yangyang Li, Hongguang Lu, Xian Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species biology Process Chemistry and Technology General Chemical Engineering medicine.medical_treatment Near-infrared spectroscopy food and beverages Photodynamic therapy Far-red 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences Fluorescence 0104 chemical sciences chemistry Biophysics medicine Photosensitizer Aggregation-induced emission 0210 nano-technology Bacteria |
| Zdroj: | Dyes and Pigments. 165:53-57 |
| ISSN: | 0143-7208 |
| DOI: | 10.1016/j.dyepig.2019.02.019 |
| Popis: | Bacterial infection poses great threats to human health and the emergence of drug-resistant bacteria requires effective methods to eliminate bacteria and avoid bacterial resistant. Photodynamic therapy (PDT), which applies photosensitizers (PSs) to generate reactive oxygen species (ROS) under light irradiation, has attracted widespread concern on bacterial treatment, recently. In this work, we develop a far red/near-infrared (FR/NIR)-emissive fluorescent molecule, AIE-TEA, with aggregation-induced emission (AIE) characteristics, for FR/NIR imaging and PDT of bacteria. Due to AIE characteristics and a certain degree of water dispersity, the AIE-TEA can conduct imaging of bacteria without wash process. Moreover, the AIE-TEA can effectively generate ROS under ultralow power white light irradiation (20 mW cm−2) with quantum yield of up to 83%, which is crucial for PDT of bacteria. The AIE-TEA can selectively kill Gram-positive bacteria (S. aureus) via image-guided PDT. |
| Databáze: | OpenAIRE |
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