Regio- and Stereo-selective Bioreduction of Diketo-n-butylphosphonate by Baker's Yeast

Autor:	Chengye Yuan, Jinfeng Li, Ke Wang, Zu-Yi Li
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Trifluoromethyl genetic structures Biotransformation Chemistry Stereochemistry Yield (chemistry) Hydroxy group Moiety Organic chemistry General Chemistry Yeast
Zdroj:	Chinese Journal of Chemistry. 20:1379-1387
ISSN:	1001-604X
DOI:	10.1002/cjoc.20020201138
Popis:	A regio- and stereo-selective reduction of diketo-n-butylphosphonates by baker's yeast was reported. The chemical yield and ee value of these reactions are highly dependent on the structure of substrates. The resulting optical active hydroxyalkanephosphonates can be used as chirons for the synthesis of polyfunctional organophosphorus compounds. As useful building block, a series of α, β-unsaturated ketones bearing chiral hydroxy group in addition to trifluoromethyl moiety was prepared via the Homer-Wadsworth-Emmons (HWE) reaction of the biotransformation products.
Databáze:	OpenAIRE
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