Iodine catalyzed one-pot four component synthesis of coumarinyl phosphoramidates via sequential addition of reactants

Autor:	Mohammed Imrankhan, Kalegowda Shivashankar
Rok vydání:	2020
Předmět:	Ethanol chemistry.chemical_element Phosphoramidate General Chemistry Iodine Combinatorial chemistry Catalysis Solvent chemistry.chemical_compound chemistry Materials Chemistry Nucleophilic substitution Sodium azide Phenols
Zdroj:	New Journal of Chemistry. 44:18573-18578
ISSN:	1369-9261 1144-0546
DOI:	10.1039/d0nj04445h
Popis:	An unprecedented synthetic route for the preparation of a library of novel coumarinyl phosphoramidate derivatives via iodine catalysed one-pot four component reactions of ethyl 4-bromo-3-oxo-alkanoate, sodium azide, trialkyl phosphites, and phenols in the ethanol solvent is reported here. The reaction proceeds via the nucleophilic substitution reaction, phosphoramidate rearrangement and Pechmann cyclization with C–C, C–O, C–N and N–P bond formation. The prominent features of this procedure are simple one-pot operation, cost effective, non-toxic and excellent yields of the products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::662c8619f11269b92d0c4d9cda221640 https://doi.org/10.1039/d0nj04445h Zobrazit plný text záznamu