| Popis: |
Polycystic ovary syndrome (PCOS), the commonest form of dysovulatoy infertility is a major form of heterogeneous endocrinopathy comprised of broad spectra of ovarian disorders including anovulation, hyperandrogenism with trademark features of metabolic syndrome (MS) like insulin resistance, obesity and dyslipidemia. Hyperhomocysteinemia, a close associate of MS and an increasingly frequent finding among PCOS women in India, poses a possible threat to these individuals with recurrent miscarriage. Micro-thrombi formation in hyperhomocysteinemic PCOS women cues toward the development of a “thrombophilic syndrome” in these women with its possible culmination in coronary artery disease later in life. However, pathophysiology of hyperhomocysteinemia in the context of PCOS and its far-reaching consequences remains unexplored. |
