Six-Year Regression and Progression of Cervical Lesions of Different Human Papillomavirus Viral Loads in Varied Histological Diagnoses
| Autor: | Qin Jing Pan, Danny V. Colombara, Shu Min Li, Wen Chen, Xun Zhang, You-Lin Qiao, Feng Chen, Jennifer S. Smith, Fang-Hui Zhao, Shaoming Wang, Jing Li, Ju Fang Shi, Jerome L. Belinson |
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| Rok vydání: | 2013 |
| Předmět: |
Colposcopy
Gynecology medicine.medical_specialty biology medicine.diagnostic_test business.industry Hazard ratio Obstetrics and Gynecology biology.organism_classification Cervical intraepithelial neoplasia medicine.disease female genital diseases and pregnancy complications Oncology Internal medicine medicine Biomarker (medicine) Cumulative incidence Papillomaviridae business Viral load Mass screening |
| Zdroj: | International Journal of Gynecological Cancer. 23:716-723 |
| ISSN: | 1048-891X |
| Popis: | Objective This study aims to evaluate human papillomavirus (HPV) viral loads as a biomarker for triage into colposcopy and cervical intraepithelial neoplasia grade 2 (CIN2) therapy to reduce the colposcopy referral rate and CIN2 overtreatment in low-resource settings. Methods In 1999, 1997 women aged 35 to 45 years in Shanxi, China, received 6 cervical screenings with pathological confirmation. In 2005, 1461 histologically normal women, 99 with CIN grade 1 (CIN1), and 30 with CIN2 or worse (CIN2+) were rescreened in a follow-up study. Human papillomavirus was detected by Hybrid Capture 2. Viral load, estimated by the ratio of relative light units to standard positive control (RLU/PC), was categorized into 4 groups: negative ( Results Cumulative incidence of CIN2+ increased with baseline HPV viral loads among normal women and women with CIN1 at baseline (P-trend Conclusions Locales using HPV testing as the primary screening method and lacking high-quality cytology-based screening should consider viral load as an alternative to colposcopy triage for women older than 35 years. Viral loads may also predict CIN2 progression until additional biomarkers become available. |
| Databáze: | OpenAIRE |
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