| Autor: |
RANDALL H. FRIEDLINE, MAHAA ALBUSHARIF, HYE LIM NOH, ALLISON M. KIM, LAUREN H. KIM, DORIS X.T. ZHENG, GLENNA SWINAND, ANNIKA BEAVERSON, XIAODI HU, LAUREN A. TAUER, WERNER MULLER, JASON K. KIM |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Diabetes. 71 |
| ISSN: |
0012-1797 |
| Popis: |
Nonalcoholic steatohepatitis (NASH) is a major complication of obesity, and interferon-γ (IFNγ) is a key regulator of innate and adaptive immunity by priming macrophages and inducing an inflammatory response. We have recently generated mice with conditional deletion of IFNγ receptor in myeloid cells (Lyz-IFNγR2 KO) . After weeks of high-fat diet (HFD) , male KO and wild-type (WT) mice (n=6) developed fatty liver with a 70% increase in hepatic triglyceride levels compared to chow-fed mice (Figure 1; *P In conclusion, our findings identify myeloid IFNγ signaling as a potential therapeutic target in treating metabolic liver disease. Disclosure R.H.Friedline: None. L.A.Tauer: None. W.Muller: None. J.K.Kim: n/a. M.Albusharif: None. H.Noh: n/a. A.M.Kim: None. L.H.Kim: None. D.X.T.Zheng: None. G.Swinand: None. A.Beaverson: None. X.Hu: None. Funding National Institutes of Health (5U2CDK093000) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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