Serum Neutrophil Gelatinase- Associated Lipocalin as a Marker of Malnutrition in Maintenance Hemodialyzed Patients
| Autor: | Seham Mohammed, Enas S. Ahmad, Anas Abd AlRahman, Hesham Esaa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry medicine.medical_treatment Albumin Lipocalin medicine.disease Gastroenterology Neutrophil gelatinase-associated lipocalin Malnutrition Internal medicine medicine Serum iron General Earth and Planetary Sciences Gelatinase Hemodialysis business Dialysis General Environmental Science |
| Zdroj: | Benha Medical Journal. |
| ISSN: | 2357-0016 |
| Popis: | Background: Neutrophil Gelatinase- Associated Lipocalin (NGAL) is a useful clinical biomarker for early diagnosis, predicting disease severity, therapeutic monitoring, and for predicting clinical outcomes. Aim: The current study aimed to investigate serum Neutrophil gelatinase-associated lipocalin ( NGAL ) levels as a marker of malnutrition in maintenance hemodialysis patients. Subjects and methods: This study was conducted on 50 subjects. Subjects were divided into three groups .Group (1): Hemodialyzed patients : Included 30 patients before starting hemodialysis (HD). Group (2): The same 30 patients after hemodialysis. Group (3): Included control group. Serum levels of NGAL was measured by enzyme-linked immunosorbent assay (ELISA ). Results: There is high statistically significant decrease in NGAL in dialyzed patients after dialysis when compared to the same patients before dialysis (p < 0.001). There is statistically significant positive correlation between NGAL after dialysis and albumin, pre-albumin, serum iron, serum ferritin, TLC and neutrophils %. There is a statistically significant decrease in the serum level of NGAL (before and after) in dialysis patients with malnutrition when compared to ( before and after ) dialysis patients without malnutrition. Conclusion: Serum level of NGAL seems to be a reliable marker of malnutrition appearance, allowing early diagnosis and preventive therapy. |
| Databáze: | OpenAIRE |
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