Caffeine Disposition in the Pregnant RabbitCaffeine Disposition in the Pregnant Rabbit
| Autor: | B. R. Dorrbecker, S. H. Dorrbecker, John R. Raye, Paul A. Kramer |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Lagomorpha
biology business.industry Metabolite Pharmacology biology.organism_classification chemistry.chemical_compound New Zealand white rabbit Pharmacokinetics chemistry medicine Gestation Pharmacology (medical) Theophylline General Pharmacology Toxicology and Pharmaceutics business Caffeine medicine.drug Paraxanthine |
| Zdroj: | Developmental Pharmacology and Therapeutics. 11:109-117 |
| ISSN: | 2504-2505 0379-8305 |
| DOI: | 10.1159/000457675 |
| Popis: | We studied the pharmacokinetics of caffeine in the pregnant New Zealand White rabbit, using two methods of drug administration. Ten rabbits that received a continuous intravenous infusion of caffeine (8-22 mg/kg.day) through 29 days of gestation exhibited increased plasma concentrations of caffeine and paraxanthine, its major metabolite, in the last half of gestation. Three rabbits that received intermittent intravenous bolus doses of caffeine (40 mg) exhibited areas under the caffeine plasma concentration versus time curve at 29 days of gestation that were 85-165% greater than those observed before mating. The results of these studies indicate that the elimination of caffeine is diminished in late gestation in the rabbit. |
| Databáze: | OpenAIRE |
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