| Popis: |
The growing demand for cell-based therapies drives the development of appropriate production-level biomanufacturing systems. Optimized culture conditions within these systems will likely include the relative motion of cells to medium, creating a biomechanical microenvironment that includes shear stress. Stresses such as shear, compression, and tension affect stem cell fate and function. This chapter will address the biomechanical cues in pluripotent stem cell manufacturing. Topics of discussion will include the different types of mechanical forces and the effects on stem cells, the biomechanical environment in scale-up bioreactor systems, and recent findings in pluripotent stem cell expansion and differentiation in stir-based bioreactors. |
