Dependence of SARS-CoV-2 (COVID-19) inactivation ability on the crystallinity level of transparent Cu2O thin films
| Autor: | Hsiang-Jung Wu, Takashi Douura, Kyoko Kumagai, Hiroki Nagai, Hiroshi Kawakami, Emi E. Nakayama, Tatsuo Shioda, Mitsunobu Sato |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Functional Materials Letters. 15 |
| ISSN: | 1793-7213 1793-6047 |
| DOI: | 10.1142/s1793604722510535 |
| Popis: | The inactivation ability of SARS-CoV-2 (COVID-19) was examined using two types of transparent Cu2O thin films with different crystallinities on a Na-free glass substrate. The low-crystallinity Cu2O thin film, which was fabricated by irradiating 254 nm ultraviolet (UV)-light with an intensity of 6.72 mW cm[Formula: see text] onto a spin-coated precursor film involving Cu[Formula: see text] complexes at room temperature, exhibited an outstanding COVID-19 inactivation ability to reduce 99.999% of the virus after 1 h of incubation. The X-ray diffraction results of the UV-irradiated thin film indicated a cubic Cu2O lattice with a small crystallite size of 2 ± 1 nm. Conversely, the high-crystallinity Cu2O thin film with a crystallite size of 16 ± 3 nm, obtained by heating a spin-coated precursor film containing another Cu[Formula: see text] complex, showed a negligibly low inactivation activity at the same level as the Na-free glass substrate. The eluted concentrations of Cu ions from both Cu2O thin films were analyzed after immersion in Dulbecco’s modified Eagle’s medium (DMEM) for 0.25–2 h. The eluted Cu–ion concentration of 1.16 ppm was observed for the UV-irradiated thin film by DMEM immersion after 1 h, but that of 0.04 ppm was observed for the heat-treated thin film. This indicated that an important factor of virus inactivation on Cu2O thin films is highly related to the elution of Cu ions that occurred from the surface in the medium. |
| Databáze: | OpenAIRE |
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