Indole diketopiperazine alkaloids and aromatic polyketides from the Antarctic fungus Penicillium sp. SCSIO 05705

Autor:	Weihao Chen, Junfeng Wang, Fa-Zuo Wang, Meng-Meng Song, Xin-Peng Tian, Yonghong Liu, Yi-Wei Hu, Xiaoyan Pang
Rok vydání:	2021
Předmět:	Indole test Circular dichroism biology Indole alkaloid Stereochemistry Alkaloid Organic Chemistry Absolute configuration Plant Science biology.organism_classification Biochemistry Acetylcholinesterase Analytical Chemistry chemistry.chemical_compound chemistry Penicillium Butenolide
Zdroj:	Natural Product Research. 37:389-396
ISSN:	1478-6427 1478-6419
Popis:	A new indole diketopiperazine alkaloid, named penilline D (1), together with five known indole alkaloid analogues (2-5, 11), two meroterpenoids (6 and 12), and four butenolide derivatives (7-10), were isolated from the Antarctic fungus Penicillium sp. SCSIO 05705. Extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation were used to elucidate the structure of penilline D (1), including its absolute configuration. All isolated compounds (1-12) were evaluated for their cytotoxic, antibacterial and enzyme inhibitory activities against acetylcholinesterase (AChE) and pancreatic lipase (PL). Among them, compound 5 exhibited moderate in vitro cytotoxic activity against the 143B cell line with IC50 value of 12.64 ± 0.78 μM. Compound 6 showed strong inhibitory activity against AChE with IC50 value of 0.36 nM (IC50 18.7 nM for Tacrine), while compounds 6 and 11 showed weak PL enzyme inhibitory activity. Furthermore, an in silico molecular docking study was also performed between 6 and AChE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::660693d38a4d136a62ef355f496c02c2 https://doi.org/10.1080/14786419.2021.1973460 Zobrazit plný text záznamu