| Autor: |
Jim-Min Fang, Wei-Feng Fang, Yu-Tzu Chen, Kuan-Hung Chen, Jing-Tang Yang |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Chemical Engineering Journal. :33-37 |
| ISSN: |
1385-8947 |
| DOI: |
10.1016/j.cej.2012.05.061 |
| Popis: |
The advantageous features of a split-and-recombination (SAR) microreactor for organic synthesis of labile bioactive compounds are demonstrated with rapid and efficient cross-coupling reactions of two monophosphate components to form a saccharide–nucleoside diphosphate. With this microreactor possessing the SAR mechanism that dramatically enlarges the material interface to promote the fluidic mixing, 85% conversion of a cross-coupling reaction (GlcNAc monophosphate reacting with UMP-morpholidate) to the diphosphate (acetylated UDP-GlcNAc) was achieved in 10 s, which is a small fraction of the two days for 80% conversion with a conventional batch reactor; the duration of reaction is hence decreased 105 fold. Diphosphate from another cross-coupling reaction (GlcNAc monophosphate reacting with phosphoro-p-anisidate) was prepared in 94% yield (HPLC analysis) over a reaction duration 90 s with this microreactor; furthermore, 1 mg of the resulting compound was obtained in ∼20 min. An abbreviated duration and satisfactory output are expected to be realized when several SAR microreactors are applied in parallel. By means of this microreactor technique, a synthesis with burdensome and protracted procedures becomes facile to generate products with great efficiency. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect