Mechanistic insight into oxidizedN,N-dimethylacetamide as a source of formaldehyde related derivatives
| Autor: | Daniel Zewge, Xiaoyi Gong, Yizhou Liu, Zhu Liu, Brett Harman, Xiaodong Bu, Huaming Sheng, Mikhail Reibarkh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Fluid Flow and Transfer Processes
010405 organic chemistry Process Chemistry and Technology Formaldehyde Related derivatives 010402 general chemistry 01 natural sciences Catalysis Dimethylacetamide 0104 chemical sciences chemistry.chemical_compound chemistry Chemistry (miscellaneous) Hemiaminal Chemical Engineering (miscellaneous) Organic chemistry |
| Zdroj: | Reaction Chemistry & Engineering. 3:146-150 |
| ISSN: | 2058-9883 |
| Popis: | A hemiaminal derivative identified during preparation of the penultimate of ceftolozane 1, mandated a thorough investigation of the source of the impurity. N,N-Dimethylacetamide (DMAc) subjected to oxidation was found to be the culprit generating oxidized products that serve as sources of the hemiaminal derivative. Identification of DMAc as a source of formaldehyde derivatives and the mechanism of DMAc oxidation are elaborated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|